Pharmaceuticals Testing Attachments for Tablet Strength, Coating Adhesion, Mucoadhesion

Any of the texture analyser range can be used for the product tests listed below.

A selection of special attachments and typical measurements are also shown which are commonly used in this application area. However, this does not show the complete range of attachments available for the testing of pharmaceutical products. Test procedures include: compression, puncture/penetration, tension, fracture/bending, extrusion, cutting/shearing.

Typical measurements include:

Bloom strength: gelatin gels
Gel Strength and Gel-Forming Properties: wound dressings, jelly lubricants, contact lenses, soft gel capsules, suppositories
Elasticity & Rupture Force: capsules, breast implants, coronary stents
Tablet Strength
Swelling and Disintegration: tablets
Tablet Coating Adhesion
Mucoadhesion
Bioadhesion: transdermal patches, films
Compressibility: powders, granules, pellets
Breaking Strength: bones, artificial limbs, alginate rafts, hard capsules
Syringeability: biogels
Consistency: creams
Adhesiveness: sputum, biogels, dentistry amalgums


Tablet Strength This diametral crush test identifies important differences in tablet characteristics missed by conventional tablet strength testers, which only measure the point force at which the tablet breaks.	Gels Standard probes such as that required for gelatine testing (BS 757), as shown above, are available for the assessment of Bloom strength/Gel strength or rupture characteristics of gels.	Tablet Coating Adhesion Fixture This test provides a quantitative measure of the adhesion strength of the coating to the tablet surface. Such a test is useful for studying the consequences of changes in tablet coating formulation variables.

Mucoadhesion Test Rig Tests of solid dosage forms, semi- solids such as ointments and gels and even systems which solidify on contact with the target organ can be performed.	Bilayer Tablet Shear Rig (Registered Design) This rig enables tablet layer separation to be quantified.	Syringe Testing Rig (Registered Design) Allows measurement of the aspiration and extraction forces of syringes.

Cylinder probes Can be used to assess granule compressibility.	Capsule Loop Tensile Rig (Registered Design) This rig measures the force required to split one half of a hard gel capsule.	Cylinder probes (small/large diameter) Can be used to assess puncture/ compression force of e.g. capsules.

Powder Compaction Rig (Registered Design) Allows measurement of the compaction forces of powders.	Tube/Sachet Extrusion Rig Allows manufacturers to measure the ease of removal and application of products such as sauces, pastes, creams and gels.	Mini 3 Point Bend Rig Ideally suited to small diameter samples such as tablets. Sample supports can provide a 2mm separation.

Film Support Rig This rig allows testing of thin, film- like products to measure the burst strength, resilience and relaxation properties.	Acoustic Emission and Video Playback Allow the collection of acoustic data during a test and the synchronisation of force data with video frames - of particular interest for the testing of brittle products.	Alginate Raft Hook (British Pharmacopoeia) Allows measurement of alginate raft strength.

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Application Studies are available for the testing of PHARMACEUTICAL products using the TA.XT2i, TA.XTplus, TA.XTExpress or TA.HDplus texture analysers.

In addition, scientific papers have been published which reference the use of the TA.XT2i/TA.XTplus/TA.HDplus in the testing of PHARMACEUTICAL products.
Click here for paper titles and citation details.

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