Any of the texture analyser range can be used for the product tests listed.
A selection of special attachments and typical measurements which are commonly used in this application area are shown, although this does not necessarily include the complete range available for the testing of controlled release products. Test procedures include: compression, puncture / penetration, tension, fracture / bending, extrusion, cutting / shearing.
Typical measurements include: • Powder compaction forces of powders • Granule compressibility / fracture strength • Indentation hardness • Mechanical / tensile strength • Tablet layer separation • Rate of disintegration • Progressive swelling behaviour • Adhesion strength • Capsule burst strength • Film tensile properties • Peel strength • Peeling characteristics • Adhesive cohesion • Extrudability • Gel strength •
Developing a Controlled Release product
The stability of a pharmaceutical product is paramount to the consumer's acceptance of it, as well as to its subsequent efficacy and safety.
Development of new excipients and drug delivery systems can be challenging as effectiveness, and perhaps cost, benefits can be mitigated when quality control problems arise during manufacturing. It is vital, therefore, that manufacturers scientifically assess any potential changes in the structure or character of their products throughout formulation, processing and distribution. That is where texture analysis plays a role in providing real-time information on the effects on physical quality of active ingredients, inactive ingredients and finished products.
The desired goal is to design and develop processes that can consistently ensure a predefined quality at the end of the manufacturing process. Texture analysis instrumentation enables manufacturers to do just this, offering targeted, repeatable testing that produces actionable data. As the pharmaceutical industry innovates, so materials analysis evolves, developing and adapting to provide new instruments and methodologies for emerging requirements.