Controlled Release Product Testing Attachments

A range of CONTROLLED RELEASE PRODUCT test methods is built into Exponent Texture Analyser software and will automatically load at the click of a button.

Testing properties of controlled release products with a texture analyser

Any of the texture analyser range can be used for the product tests listed.

A selection of special attachments and typical measurements which are commonly used in this application area are shown, although this does not necessarily include the complete range available for the testing of controlled release products. Test procedures include: compression, puncture / penetration, tension, fracture / bending, extrusion, cutting / shearing.

Typical measurements include: • Powder compaction forces of powders • Granule compressibility / fracture strength • Indentation hardness • Mechanical / tensile strength • Tablet layer separation • Rate of disintegration • Progressive swelling behaviour • Adhesion strength • Capsule burst strength • Film tensile properties • Peel strength • Peeling characteristics • Adhesive cohesion • Extrudability • Gel strength •

Developing a Controlled Release product

The stability of a pharmaceutical product is paramount to the consumer's acceptance of it, as well as to its subsequent efficacy and safety.

Development of new excipients and drug delivery systems can be challenging as effectiveness, and perhaps cost, benefits can be mitigated when quality control problems arise during manufacturing. It is vital, therefore, that manufacturers scientifically assess any potential changes in the structure or character of their products throughout formulation, processing and distribution. That is where texture analysis plays a role in providing real-time information on the effects on physical quality of active ingredients, inactive ingredients and finished products.

The desired goal is to design and develop processes that can consistently ensure a predefined quality at the end of the manufacturing process. Texture analysis instrumentation enables manufacturers to do just this, offering targeted, repeatable testing that produces actionable data. As the pharmaceutical industry innovates, so materials analysis evolves, developing and adapting to provide new instruments and methodologies for emerging requirements.


Oral delivery

Tablet Indentation Hardness test

Tablet Hardness

Indentation hardness utilises a spherical probe to apply a specified load to characterise tabletting performance of individual components and mixtures.
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Tablet Strength tests

Tablet Strength

Mechanical strength is an important determinant of tablet drug release; diametral compression provides objective failure behaviour used to monitor and control the degree of compaction.
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Mini 3 Point Bend Rig

Mini Three Point Bend Rig

Allows measurement of mechanical / tensile strength of small diameter tablets, indicating ability to withstand the rigours of handling, transportation, dispensing and usage.
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Tablet Coating Adhesion test

Tablet Coating Adhesion

Provides a quantitative measure of the adhesion strength of the coating to the tablet surface which is useful for studying the consequences of tablet coating formulation change.
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Film Tensile Strength test

Tensile Grips

Allow the investigation of tensile properties of candidate films and thus the clinical performance of the final drug delivery device formulation.
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Transdermal / Dermal delivery

Adhesive test on 90° Peel Rig

90° Peel Rig

Peel strength of films or patch formulations can be investigated using porcine or synthetic skin secured to the sliding platform of a 90 degree peel rig.
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Adhesive bandage test on 180° Peel Rig

180° Peel Rig

For determination of the comparative 180° peeling or stripping characteristics which are essential for the application of adhesive bandages, dressings or patches.
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Adhesion test using a Peltier Plate

Peltier Plate

Adhesive testing performed at constant temperature (e.g. 35°C for skin controlled by a Peltier Plate attached to a texture analyser) provides a more accurate measurement.
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Back Extrusion Rig

Back Extrusion Rig

Assesses the consistency or extrudability of such products as gels, creams and lotions which affects removal from containers and product application.
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Parenteral delivery

Gel Bloom test

Gel properties

Typical measurements include gel strength, Bloom strength (according to ISO standard), rupture force, adhesiveness, gel forming points and elasticity/brittleness.
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Adhesion test using a Peltier Plate

Peltier Plate

Adhesive testing performed at constant temperature (e.g. 35°C for skin controlled by a Peltier Plate attached to a texture analyser) provides a more accurate measurement.
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Back Extrusion Rig

Back Extrusion Rig

Assesses the consistency or extrudability of such products as gels, creams and lotions which affects removal from containers and product application.
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Pulmonary delivery

Mucosal delivery

Rectal delivery

Inhaler Support Rig

Inhaler Support Rig

Enables the performance of the metering valve to be assessed using a hemispherical probe which best mimics the action of the finger for drug delivery.
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Mucoadhesion Test Rig

Mucoadhesion Rig

Mucoadhesion measurement of solid dosage forms, semi-solids and even systems which solidify on contact with the target organ can be performed.
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Needle Probe Suppository Penetration test

Suppository Penetration

Enables suppositories to be accurately evaluated to compare differences in ingredients, processing conditions and behaviour under different temperature conditions.
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Vaginal delivery

Ocular delivery